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KMID : 1022820120030020033
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Journal of Multiple Sclerosis and Neuroimmunology
2012 Volume.3 No. 2 p.33 ~ p.37
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Neuromyelitis Optica: What’s New in 2011-2012?
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Shin Ha-Young
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Abstract
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Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system, which affects optic nerve and spinal cord preferentially. After the discovery of NMO-IgG in patients of NMO and the identification of aquaporin 4 as a target of NMO-IgG, the knowledge about NMO is growing explosively. Advances in our understanding of the patho-mechanism of NMO have identified new targets for future therapeutic efforts, including anti-aquaporin-4 monoclonal antibody blocker and neutrophil protease inhibition. This review highlights the recent advances in current treatment and future therapeutic approaches.
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KEYWORD
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Neuromyelitis optica, Devic’s disease, Anti-Aquaporin-4 antibody
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